Recent Collaborations

with Alex Wilson, Department of Biology, University of Miami

Amino acid transporters involved in insect-bacteria symbiosis.

 

Feng, H., Edwards, N., Anderson, C.M.H., Althaus, M., Duncan, R.P., Hsu, Y.C., Luetje, C.W., Price, D.R.G., Wilson, A.C.C., Thwaites, D.T. (2019) Trading amino acids at the aphid/Buchnera symbiotic interface.  Proceedings of theNational Academy of Sciences 116: 16003-16011.

 

Price, D.R.G., Wilson, A.C.C., Luetje, C.W. (2015) Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1.  Biochimica et Biophysica Acta – Biomembranes 1848: 2085-2091.

 

Price, D.R.G., Feng, H., Baker, J.D., Bavan, S., Luetje, C.W., Wilson, A.C.C. (2014) Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts. Proceedings of the National Academy of Sciences 111: 320-325.

 

 

with Ivy Carroll, RTI International

The functional effects of modifications to the structure of epibatidine, an exceptionally potent nicotinic agonist. 

 

Ondachi, P., Castro, A.H., Sherman, B., Luetje, C.W., Wageman, C.R., Marks, M.J., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2017) Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacological properties of 2’-fluoro- (substituted thiophenyl) deschloroepibatidine analogs.  ACS ChemicalNeuroscience 8: 115-127.

 

Ondachi, P., Castro, A.H., Luetje, C.W., Wageman, C.R., Marks, M.J., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2016) Synthesis, nicotinic acetylcholine binding, in vitro and in vivo pharmacological properties of 2’-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogs. ACS Chemical Neuroscience 7: 1004-1012.

 

Ondachi, P., Ye, Z., Castro, A.H., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2015) Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3¢-(substituted pyridinyl)-deschloroepibatidine analogues. Bioorganic & Medicinal Chemistry 23: 5693-5701.

 

Carroll, F.I., Navarro, H.A., Mascarella, S.W., Castro, A.H., Luetje, C.W., Wageman, C.R., Marks, M.J., Jackson, A., Damaj, M.I. (2015) In vitro and in vivo neuronal nicotinic receptor properties of (+)- and (-)- pyrido[3,4] homotropane [(+)- and (-)-PHT]. (+)-PHT is a potent and selective full agonist at α6β2 containing neuronal nicotinic acetylcholine receptors. ACS Chemical Neuroscience 6: 920-926.

 

Ondachi, P., Castro, A.H., Bartkowiak, J.M., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2014) Synthesis, Nicotinic Acetylcholine Receptor Binding and Antinociceptive Properties of 2'-Fluoro-3'-(Substituted pyridinyl)-7-deschloroepibatidine Analogues.  Journal of Medicinal Chemistry 57: 836-848.

 

Ondachi, P., Castro, A., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2012) Synthesis and Nicotinic Acetylcholine Receptor In Vitro and In Vivo Pharmacological Properties of 2'-Fluoro-3'-(substituted phenyl)deschloroepibatidine Analogs of 2'-Fluoro-3'-(4-nitrophenyl)deschloroepibatidine (4-Nitro-PFEB or RTI-7527-102).  Journal of Medicinal Chemistry 55: 6512-6522.

 

Mihalak, K.B., Carroll, F.I., Luetje, C.W. (2006) Varenicline is a partial agonist at a4b2 and a full agonist at a7 neuronal nicotinic receptors.  Molecular Pharmacology 70: 801-805.

 

Avalos, M, Parker, M.J., Maddox, F.N., Carroll, F.I. and Luetje, C.W. (2002) Effects of pyridine ring substitutions on the affinity, efficacy and subtype selectivity of the neuronal nicotinic receptor agonist epibatidine. Journal of Pharmacologyand Experimental Therapeutics 302: 1246-1252.

 

 

with Walter Leal, University of California, Davis

Odorant receptors of Culex quinquefasciatus, the Southern House Mosquito.

 

Hughes, D.T., Pelletier, J., Rahman, S., Chen, S., Leal, W.S., Luetje, C.W. (2017) Functional and non-functional forms of Cqui\Or91, an odorant selectivity subunit of Culex quinquefasciatusChemical Senses 42: 333-341.

 

Xu, P., Choo, Y.-M., Pelletier, J., Sujimoto, F.R., Hughes, D.T., Zhu, F., Atungulu, E., Cornel, A.J., Luetje, C.W., Leal, W.S. (2013) Silent, Generic and Plant Kairomone Sensitive Odorant Receptors from the Southern House Mosquito. Journal of Insect Physiology 59: 961-966.

 

Hughes, D.T., Pelletier, J., Luetje, C.W., Leal, W.S. (2010) Odorant Receptor from the Southern House Mosquito Narrowly Tuned to the Oviposition Attractant Skatole.  Journal of Chemical Ecology 36: 797-800.

 

Pelletier, J., Hughes, D.T., Luetje, C.W., Leal, W.S. (2010) An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants. PLoS One 5: e10090.

 

 

with Hugh Robertson, University of Illinois, Urbana-Champaign

Insect pheromone receptors.

 

Mitchell, R.F., Hughes, D.T., Luetje, C.W., Millar, J.G., Soriano-Agaton, F., Hanks, L.M., Robertson, H.M. (2012) Sequencing and characterizing the odorant receptors of the cerambycid beetle Megacyllene caryae (Coleoptera: Cerambycidae).  Insect Biochemistry and Molecular Biology 42: 499-505.

 

Wanner, K.W., Nichols A.S., Allen, J.E., Bunger, P., Garczynski, S.F., Linn, C.E. Jr., Robertson, H.M., Luetje, C.W. (2010) Sex Pheromone Receptor Specificity in the European Corn Borer Moth, Ostrinia nubilalisPLoS One 5: e8685. 

 

Wanner, K.W., Nichols, A.S., Walden, K.K.O., Brockmann, A., Luetje, C.W., Robertson, H.M. (2007) A honeybee odorant receptor for the queen substance 9-oxo-2-decenoic acid.  Proceedings of the National Academy of Sciences 104: 14383-14388.  

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