The Luetje Lab research interests lie within the general area of receptor structure and function, with a particular emphasis on ligand recognition.  The central focus of our research program is currently the olfactory receptors of disease vector mosquitoes.  We also continue to study the olfactory receptors of mammals and the nicotinic acetylcholine receptors of the mammalian nervous system.  We use a variety of techniques including conventional mutagenesis, substituted cysteine accessibility mutagenesis, functional assay by robotic electrophysiology, and computational receptor modeling and virtual ligand docking.