Publications
Duncan, R.P., Anderson, C.M.H., Thwaites, D.T., Luetje, C.W., Wilson, A.C.C. (2023) Co-option of a conserved host glutamine transporter facilitates aphid/Buchnera metabolic integration. Proceedings of the National Academy of Sciences, in press.
Feng, H., Edwards, N., Anderson, C.M.H., Althaus, M., Duncan, R.P., Hsu, Y.C., Luetje, C.W., Price, D.R.G., Wilson, A.C.C., Thwaites, D.T. (2019) Trading amino acids at the aphid/Buchnera symbiotic interface. Proceedings of the National Academy of Sciences 116: 16003-16011.
Kepchia, D., Xu, P., Terryn, R., Castro, A., Schürer, S., Leal, W.S., Luetje, C.W. (2019) Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit. Scientific Reports, 9: 4055.
Rahman, S., Luetje, C.W. (2017) Mutant cycle analysis identifies a ligand interaction site in an odorant receptor of the malaria vector Anopheles gambiae. Journal of Biological Chemistry 292: 18916-18923.
Kepchia, D., Sherman, B., Haddad, R., Luetje, C.W. (2017) Mammalian Odorant Receptor Tuning Breadth Persists Across Distinct Odorant Panels. PLoS One 12: e0185329.
Kepchia, D. Moliver, S., Phillips, C., Chohan, K., Luetje, C.W. (2017) Inhibition of insect olfactory behavior by an airborne antagonist of the insect odorant receptor co-receptor subunit. PLoS One 12: e0177454.
Hughes, D.T., Pelletier, J., Rahman, S., Chen, S., Leal, W.S., Luetje, C.W. (2017) Functional and non-functional forms of Cqui\Or91, an odorant selectivity subunit of Culex quinquefasciatus. Chemical Senses 42: 333-341.
Ondachi, P., Castro, A.H., Sherman, B., Luetje, C.W., Wageman, C.R., Marks, M.J., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2017) Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacological properties of 2’-fluoro-(substituted thiophenyl)deschloroepibatidine analogs. ACS Chemical Neuroscience 8: 115-127.
Ondachi, P., Castro, A.H., Luetje, C.W., Wageman, C.R., Marks, M.J., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2016) Synthesis, nicotinic acetylcholine binding, in vitro and in vivo pharmacological properties of 2’-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogs. ACS Chemical Neuroscience 7: 1004-1012.
Ondachi, P., Ye, Z., Castro, A.H., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2015) Synthesis, nicotinic acetylcholine receptor binding, in vitro and in vivo pharmacology properties of 3'-(substituted pyridinyl)-deschloroepibatidine analogues. Bioorganic & Medicinal Chemistry 23: 5693-5701.
Price, D.R.G., Wilson, A.C.C., Luetje, C.W. (2015) Proton-dependent glutamine uptake by aphid bacteriocyte amino acid transporter ApGLNT1. Biochimica et Biophysica Acta - Biomembranes 1848: 2085-2091.
Carroll, F.I., Navarro, H.A., Mascarella, S.W., Castro, A.H., Luetje, C.W., Wageman, C.R., Marks, M.J., Jackson, A., Damaj, M.I. (2015) In vitro and in vivo neuronal nicotinic receptor properties of (+)- and (-)- pyrido[3,4] homotropane [(+)- and (-)-PHT]. (+)-PHT is a potent and selective full agonist at α6β2 containing neuronal nicotinic acetylcholine receptors. ACS Chemical Neuroscience 6: 920-926.
Li, J., Haddad, R., Santos, V., Bavan, S., Luetje, C.W. (2015) Receptive range analysis of a mouse odorant receptor subfamily. Journal of Neurochemistry 134: 47-55.
Hughes, D.T., Wang, G., Zwiebel, L., Luetje, C.W. (2014) A determinant of odorant specificity at the border of extracellular loop 2 and transmembrane domain 4 in an Anopheles gambiae odorant receptor subunit. Chemical Senses 39: 761-769.
Chen, S., Luetje, C.W. (2014) Trace amines inhibit insect olfactory receptor function through antagonism of the co-receptor subunit. F1000Research 3: 84.
Bavan, S., Sherman, B., Luetje, C.W., Abaffy, T. (2014) Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. PLoS One 9: e92064.
Ondachi, P., Castro, A.H., Bartkowiak, J.M., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2014) Synthesis, Nicotinic Acetylcholine Receptor Binding and Antinociceptive Properties of 2'-Fluoro-3'-(Substituted pyridinyl)-7-deschloroepibatidine Analogues. Journal of Medicinal Chemistry 57: 836-848.
Price, D.R.G., Feng, H., Baker, J.D., Bavan, S., Luetje, C.W., Wilson, A.C.C. (2014) Aphid amino acid transporter regulates glutamine supply to intracellular bacterial symbionts. Proceedings of the National Academy of Sciences 111: 320-325.
Chen, S., Luetje, C.W. (2013) Phenylthiophenecarboxamide antagonists of the insect odorant receptor co-receptor subunit from a mosquito. PLoS One 8: e84575.
Xu, P., Choo, Y.-M., Pelletier, J., Sujimoto, F.R., Hughes, D.T., Zhu, F., Atungulu, E., Cornel, A.J., Luetje, C.W., Leal, W.S. (2013) Silent, Generic and Plant Kairomone Sensitive Odorant Receptors from the Southern House Mosquito. Journal of Insect Physiology 59: 961-966.
Luetje, C.W. (2013) Chemical courtship in mice. Nature Chemical Biology 9:140-141.
Luetje, C.W., Nichols A.S., Castro A., Sherman B.L. (2013) Functional assay of mammalian and insect olfactory receptors using Xenopus oocytes. Methods in Molecular Biology 1003:187-202.
Ondachi, P., Castro, A., Luetje, C.W., Damaj, M.I., Mascarella, W.W., Navarro, H.A., Carroll, F.I. (2012) Synthesis and Nicotinic Acetylcholine Receptor In Vitro and In Vivo Pharmacological Properties of 2'-Fluoro-3'-(substituted phenyl)deschloroepibatidine Analogs of 2'-Fluoro-3'-(4-nitrophenyl)deschloroepibatidine (4-Nitro-PFEB or RTI-7527-102). Journal of Medicinal Chemistry 55(14):6512-22.
Chen, S., Luetje, C.W. (2012) Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit. PLoS ONE 7(5): e36784.
Li, J., Haddad, R., Chen, S., Santos, V., Luetje, C.W. (2012) A broadly tuned mouse odorant receptor that detects nitrotoluenes. Journal of Neurochemistry 121(6):881-890.
Mitchell, R.F., Hughes, D.T., Luetje, C.W., Millar, J.G., Soriano-Agaton, F., Hanks, L.M., Robertson, H.M. (2012) Sequencing and characterizing the odorant receptors of the cerambycid beetle Megacyllene caryae (Coleoptera: Cerambycidae). Insect Biochemistry and Molecular Biology 42(7):499-505.
Franco, A., Kompella, S.N., Akondi, K., Melaun, C., Daly, N., Luetje, C.W., Alewood, P.F., Craik, D.J., Adams, D.J., Mari, F. (2011) RegIIA: An α4/7-conotoxin from the venom of Conus regius that potently blocks a3b4 nAChRs. Biochemical Pharmacology 83:419-426.
Goldsmith, B.R., Mitala, Jr., J.J., Josue, J., Castro, A., Lerner, M.B., Bayburt, T.H., Khamis, S.M., Jones, R.A., Brand, J.G., Sligar, S.G., Luetje, C.W., Gelperin, A., Rhodes, P.A., Discher, B.M., Johnson, A.T.C. (2011) Biomimetic chemical sensors using nanoelectronic read out of olfactory receptor proteins. ACS Nano 5:5408-5416.
Nichols, A.S., Chen, S., Luetje, C.W. (2011) Subunit Contributions to Insect Olfactory Receptor Function: Channel block and odorant recognition. Chemical Senses 36:781-790.
Hughes, D.T., Pelletier, J., Luetje, C.W., Leal, W.S. (2010) Odorant Receptor from the Southern House Mosquito Narrowly Tuned to the Oviposition Attractant Skatole. Journal of Chemical Ecology 36(8):797-800.
Pelletier, J., Hughes, D.T., Luetje, C.W., Leal, W.S. (2010) An odorant receptor from the southern house mosquito Culex pipiens quinquefasciatus sensitive to oviposition attractants. PLoS ONE 5(4): e10090.
Nichols, A.S., Luetje, C.W. (2010) Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions. Journal of Biological Chemistry 285:11854-11862.
Wanner, K.W., Nichols A.S., Allen, J.E., Bunger, P., Garczynski, S.F., Linn, C.E. Jr., Robertson, H.M., Luetje, C.W. (2010) Sex Pheromone Receptor Specificity in the European Corn Borer Moth, Ostrinia nubilalis. PLoS ONE 5(1): e8685.
Repicky, S.E., Luetje, C.W. (2009) Molecular receptive range variation among mouse odorant receptors for aliphatic carboxylic acids. Journal of Neurochemistry 109:193-202.
Hsiao, B., Mihalak, K.B., Magleby, K.L., Luetje, C.W. (2008) Zinc potentiates neuronal nicotinic receptors by increasing burst duration. Journal of Neurophysiology 99:999-1007.
Menashe, I., Abaffy, T., Hasin, Y., Goshen, S., Yahalom, V., Luetje, C.W., Lancet, D. (2007) Genetic Elucidation of Human Hyperosmia to Isovaleric Acid. PLoS Biology 5(11): e284.
Wanner*, K.W., Nichols*, A.S., Walden, K.K.O., Brockmann, A., Luetje, C.W., Robertson, H.M. (2007) A honeybee odorant receptor for the queen substance 9-oxo-2-decenoic acid. Proceedings of the National Academy of Sciences 104:14383-14388. *equal contributions
Abaffy, T., Malhotra, A., Luetje, C.W. (2007) The molecular basis for ligand specificity in a mouse olfactory receptor: A network of functionally important residues. Journal of Biological Chemistry 282:1216-1224.
Shiembob, D.L., Roberts, R.L., Luetje, C.W., McIntosh, J.M. (2006) Determinants of alpha-conotoxin BuIA selectivity on the nicotinic acetylcholine receptor beta subunit. Biochemistry 45:11200-11207.
Mihalak, K.B., Carroll, F.I., Luetje, C.W. (2006) Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors. Molecular Pharmacology 70:801-805.
Abaffy, T., Matsunami, H., Luetje, C.W. (2006) Functional analysis of a mammalian odorant receptor subfamily. Journal of Neurochemistry 97:1506-1518.
Hsiao, B., Mihalak, K.B., Repicky, S.E., Everhart, D., Mederos, A., Malhotra, A., Luetje, C.W. (2006) Determinants of zinc potentiation on the alpha4 subunit of neuronal nicotinic receptors. Molecular Pharmacology 69:27-36.
Luetje, C.W. (2004) Getting past the asterisk: The subunit composition of presynaptic nicotinic receptors that modulate striatal dopamine release. Molecular Pharmacology 65:1333-1335.
Everhart, D., Cartier, G.E., Malhotra, A., Gomes, A.V., McIntosh, J.M., and Luetje, C.W. (2004) Determinants of potency on α-conotoxin-MII, a peptide antagonist of neuronal nicotinic receptors. Biochemistry 43:2732-2737.
Maddox, F.N., Valeyev, A.Y., Poth, K., Wood, P.M., Holohean, A.M., Davidoff, R.A., Hackman, J.C., and Luetje, C.W. (2004) GABAA receptor subunit mRNA expression in cultured embryonic and adult human dorsal root ganglion neurons. Developmental Brain Research 149:143-151.
Burnstein, K.L. and Luetje, C.W. (2004) Hormone resistance: it's SMRT to fight repression. Endocrinology 145:1525-1526.
Everhart, P., Reiller, E., Mirzoian, A., McIntosh, J.M., Malhotra, A. and Luetje, C.W. (2003) Identification of residues that confer α-conotoxin PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. Journal of Pharmacology and Experimental Therapeutics 306:664-670.
Krajewski J.L., Luetje C.W. and Kramer R.H. (2003) Tyrosine phosphorylation of rod cyclic nucleotide-gated channels switches off Ca2+/calmodulin inhibition. Journal of Neuroscience 23:10100-10106.
Molokanova, E., Krajewski, J.L., Satpaev, D., Luetje, C. and Kramer, R.H. (2003) Subunit contributions to phosphorylation dependent modulation of rod cyclic nucleotide-gated channels. Journal of Physiology 552.2:345-356.
Avalos, M, Parker, M.J., Maddox, F.N., Carroll, F.I. and Luetje, C.W. (2002) Effects of pyridine ring substitutions on the affinity, efficacy and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. Journal of Pharmacology and Experimental Therapeutics 302:1246-1252.
Mirzoian, A. and Luetje, C.W. (2002) Modulation of neuronal nicotinic acetylcholine receptors by mercury. Journal of Pharmacology and Experimental Therapeutics 302:560-567.
Parker, M.J., Harvey, S.C. and Luetje, C.W. (2001). Determinants of agonist binding affinity on neuronal nicotinic receptor ß subunits. Journal of Pharmacology and Experimental Therapeutics 299:385-391.
Hsiao, B., Dweck, D. and Luetje, C.W. (2001) Subunit dependent modulation of neuronal nicotinic receptors by zinc. Journal of Neuroscience 21:1848-1856.
Molokanova, E., Maddox, F., Luetje, C.W. and Kramer, R.H. (1999) Activity-dependent modulation of rod photoreceptor cyclic nucleotide-gated channels mediated by phosphorylation of a specific tyrosine residue. Journal of Neuroscience 19:4786-4795.
Parker, M.J., Beck, A. and Luetje, C.W. (1998) Neuronal nicotinic beta2 and beta4 subunits confer large differences in agonist binding affinity. Molecular Pharmacology 54:1132-1139.
Grant, G.A., Luetje, C.W., Summers, R. and Xu, X.L. (1998) Differential Roles for Disulfide Bonds in the Structural Integrity and Biological Activity of kappa-Bungarotoxin, a Neuronal Nicotinic Acetylcholine Receptor Antagonist. Biochemistry 37:12166-12171.
Luetje, C.W., Maddox, F.N. and Harvey, S.C. (1998) Glycosylation within the cys-loop and six residues near conserved cys192/cys193 are determinants of neuronal bungarotoxin sensitivity on the neuronal nicotinic receptor alpha3 subunit. Molecular Pharmacology 53:1112-1119.
Kaiser, S.A., Soliakov., L., Harvey, S.C., Luetje, C.W. and Wonnacott, S. (1998) Differential inhibition by a-conotoxin-MII of the nicotinic stimulation of [3H]dopamine release from rat striatal synaptosomes and slices. Journal of Neurochemistry 70:1069-1076.
Harvey, S.C., McIntosh, J.M., Cartier, G.E., Maddox, F.N., and Luetje, C.W. (1997) Determinants of specificity for a-conotoxin MII on a3b2 neuronal nicotinic receptors. Molecular Pharmacology 51:336-342.
Poth, K., Nutter, T., Cuevas, J., Parker, M.J., Adams, D.J. and Luetje, C.W. (1997) Heterogeneity of nicotinic receptor class and subunit mRNA expression among individual parasympathetic neurons from rat intracardiac ganglia. Journal of Neuroscience 17:586-596.
Harvey, S.C., Maddox, F.N. and Luetje, C.W. (1996) Multiple determinants of dihydro-b-erythroidine sensitivity on rat neuronal nicotinic receptor asubunits. Journal of Neurochemistry 67:1953-1959.
Harvey, S.C. and Luetje, C.W. (1996) Determinants of competitive antagonist sensitivity on neuronal nicotinic receptor beta subunits. Journal of Neuroscience 16:3798-3806.
Earlier Publications from Charles W. Luetje
Luetje, C.W., Piattoni, M. and Patrick, J. (1993) Mapping of ligand binding sites of neuronal nicotinic receptors using chimeric alpha subunits. Molecular Pharmacology 44: 657-666.
Patrick, J. and Luetje, C.W. (1993) Pharmacological diversity of nicotine receptors. In: Biological Basis of Substance Abuse (eds. S.G. Korenman and J.D. Barchas). New York: Oxford UP, pp. 81- 94.
Patrick, J., Séguéla, P., Vernino, S., Amador, M., Luetje, C. and Dani, J.A. (1993) Functional diversity of neuronal nicotinic acetylcholine receptors. Progress in Brain Research 98: 113-120.
Vernino, S., Amador, M., Luetje, C.W., Patrick, J. and Dani, J.A. (1992) Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8: 127-134.
Luetje, C.W. and Patrick, J. (1991) Both alpha and beta subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptors. Journal of Neuroscience 11: 837-845.
Froehner, S.C., Luetje, C.W., Scotland, P.B. and Patrick, J. (1990) The postsynaptic 43K protein clusters muscle nicotinic acetylcholine receptors in Xenopus oocytes. Neuron 5: 403-410.
Luetje, C.W., Wada, K., Rogers, S., Abramson, S.N., Tsuji, K., Heinemann, S. and Patrick, J. (1990) Neurotoxins distinguish between different neuronal nicotinic acetylcholine receptor subunit combinations. Journal of Neurochemistry55: 632-640.
Luetje, C.W., Patrick, J. and Séguéla, P. (1990) Nicotine receptors in the mammalian brain. FASEB J. 4: 2753-2760.
Luetje, C.W., Tietje, K.M., Christian, J.L., and Nathanson, N.M. (1988) Differential tissue expression and developmental regulation of guanine nucleotide binding regulatory proteins and their messenger RNAs in rat heart. Journal of Biological Chemistry 263: 13357-13365.
Luetje, C.W. and Nathanson, N.M. (1988) Chronic membrane depolarization regulates the level of the guanine nucleotide binding regulatory protein Goa in cultured neuronal cells, Journal of Neurochemistry 50: 1775-1782.
Luetje, C.W., Martin, J.M., Liles, W.C., and Nathanson, N.M. (1988) Neuronal and cardiac muscarinic acetylcholine receptors: regulation and development. In: Symposia in Neuroscience 6 eds. G. Biggio, P.F. Spano, G. Toffano, and G.L. Gessa, Liviana Press-Springer Verlag, pp. 107-110.
Subers, E.M., Liles, W.C., Luetje, C.W., and Nathanson, N.M. (1988) Biochemical and Immunological Studies on the Regulation of Cardiac and Neuronal Muscarinic Acetylcholine Receptor Number and Function. In: Subtypes ofMuscarinic Receptors III: Proceedings of the Second International Symposium. Trends in Pharmacol. Sci. Suppl., eds. R.R. Levine, N.J.M. Birdsall, R.A. North, M. Holman, A. Watanabe and L.L. Iversen, Elsevier, The Netherlands, pp. 25-28.
Luetje, C.W., Brumwell, C., Norman, M.G., Peterson, G.L., Schimerlik, M.I., and Nathanson, N.M. (1987) Isolation and characterization of monoclonal antibodies specific for the cardiac muscarinic acetylcholine receptor. Biochemistry 26: 6892-6896.
Luetje, C.W., Gierschik, P., Milligan, G., Unson, C., Spiegel, A., and Nathanson, N.M. (1987) Tissue specific regulation of GTP-binding protein and muscarinic acetylcholine receptor levels during cardiac development. Biochemistry 26: 4876-4884.
Andreasen, T.J., Luetje, C.W., Heideman, W., and Storm, D.R. (1983) Purification of a novel calmodulin binding protein from bovine cerebral cortex membranes. Biochemistry 22: 4615-4618.